Bond Elut Plexa and Plexa PCX comprise an advanced generation of polymers for solid phase extraction (SPE), designed for ease of use and improved analytical performance.

Plexa and Plexa PCX are high performance polymers using novel formats and methods for high throughput automation and simple method development. Plexa PCX is designed specifically to provide a simple method for basic compounds, whereas Plexa is a general purpose choice for a wide range of acid, basic and neutral analytes. Both are ideal for applications in pharmacokinetics and pharmacodynamics, forensics and toxicology, foodstuffs and environmental investigation.

Plexa PCX uses a polymer cation exchange mechanism that combines the outstanding properties of Bond Elut Plexa - superior flow characteristics and improved analytical performance - with strong cation exchange capability. This advanced SPE sorbent effectively removes neutral and acidic interferences from the sample matrix and concentrates basic analytes, resulting in improved sensitivity, quantification and analytical performance.

The Plexa range delivers faster flow rates because the particles have much smaller interstitial paths with no fines to cause blockages. Results are more consistent and reproducible because the uniformly sized particles are near mono-dispersed, resulting in homogenous packing. Reproducible results are the norm, with very good tube-to-tube and well-to-well performance. Plexa PCX uses a simplified method for basic compounds, reducing development time and costs. In addition, the Plexa family reduces ion suppression because the highly polar, hydroxylated polymer is entirely amide-free. In contrast to other resins, the Plexa polymer has a totally wettable, but amide-free highly polar surface; the particle exterior excludes proteins and avoids strong binding of phospholipids, and so efficient removal of phospholipids from plasma is ensured.

For more information, view the User Guide (.doc)

Download Application Notes

• Fraction of Acidic,Neutral, and Basic Drugs from Plasma with Polymeric SPE Cation Exchange, Bond Elut Plexa PCX (.pdf)
• Extraction of Non-Polar Drugs from Plasma with Polymeric SPE Cation Exchange, Bond Elut Plexa PCX (.pdf)
• Extraction of Polar Drugs from Plasma with Polymeric SPE Cation Exchange, Bond Elut Plexa PCX (.pdf)

Download the Data Sheet